| | Accession Number | 5001854 |
| | Title | Comparative embryotoxicity of PCB congeners by egg injection |
| | Project Description | Polychlorinated biphenyls (PCBs) are persistent and lipophilic environmental contaminants that |
| | are ubiquitous throughout the global ecosystem. The most acutely toxic PCB congeners are |
| | environmental stressors since they assume coplanar conformations similar to dioxin. Bald eagles |
| | and terns are vulnerable as revealed by reproductive data in the Great Lakes and in New England. |
| | The utility of egg injection studies for predicting potential embryotoxicity of this class of |
| | compounds (PCBs and TCDD) compares favorably with feeding studies. Study objectives are: (1) |
| | to examine the effects of coplanar and other PCB congeners on embryonic development through |
| | hatching in multiple avian species, including American kestrels, Falco sparverius, (a model for the |
| | bald eagle) and common terns, Sterna hirundo, (populations decreasing), (2) to relate findings to |
| | field data including bioindicators such as P450 and oxidative stress for monitoring PCB |
| | contaminated ecosystems, (3) to examine combinations of different PCB congeners and other |
| | factors for interactive effects which may influence the outcome at the field level, and (4) to help |
| | establish PCB toxic equivalents for birds. |
| | Keywords | american kestrel, common tern, coplanar pcb, embryotoxic, stressor, toxic equivalents, |
| | Principal | David J Hoffman, USGS Patuxent Wildlife Research Center: david_hoffman@usgs.gov; Mark J |
| | Investigators | Melancon, USGS Patuxent Wildlife Research Center: mark_melancon@usgs.gov; |
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