Patuxent Home

Accession Number 5001854

Title Comparative embryotoxicity of PCB congeners by egg injection

Project Description Polychlorinated biphenyls (PCBs) are persistent and lipophilic environmental contaminants that

are ubiquitous throughout the global ecosystem. The most acutely toxic PCB congeners are

environmental stressors since they assume coplanar conformations similar to dioxin. Bald eagles

and terns are vulnerable as revealed by reproductive data in the Great Lakes and in New England.

The utility of egg injection studies for predicting potential embryotoxicity of this class of

compounds (PCBs and TCDD) compares favorably with feeding studies. Study objectives are: (1)

to examine the effects of coplanar and other PCB congeners on embryonic development through

hatching in multiple avian species, including American kestrels, Falco sparverius, (a model for the

bald eagle) and common terns, Sterna hirundo, (populations decreasing), (2) to relate findings to

field data including bioindicators such as P450 and oxidative stress for monitoring PCB

contaminated ecosystems, (3) to examine combinations of different PCB congeners and other

factors for interactive effects which may influence the outcome at the field level, and (4) to help

establish PCB toxic equivalents for birds.

Keywords american kestrel, common tern, coplanar pcb, embryotoxic, stressor, toxic equivalents,

Principal David J Hoffman, USGS Patuxent Wildlife Research Center:; Mark J

Investigators Melancon, USGS Patuxent Wildlife Research Center:;

Navigate PWRC SIS projects by Accession Number: First Previous Next Last

Return to SIS Projects Listing

Nav Bar link SIS List Nav Bar Link Patuxent Nav Bar Link Biological Resources Nav Bar Link USGS Nav Bar Link Interior Navigation Bar