| ||BASIS #||2309TZ 22|
| ||Title||Toxicity of lead and zinc to wildlife|
| ||Project Description||
This laboratory study on mallards investigates whether signs of lead poisoning in birds are related to damage from lipid peroxidation. Much of the literature published to date, primarily on mammals, is equivocal. Glutathione, TBARS (a measure of peroxidation), and polyunsaturated fatty acids will be studied in relation to neurologic effects, gross and histopathogical lesions, and indicators of lead poisoning in the blood.
The annual plan objectives are:1) To determine sublethal effects of lead poisoning on mallards.
2) To determine whether an antioxidant increases an animal's resistance to lead.
Relevance and Impact:
1) The results help us better
understand lead poisoning in waterfowl. This
is the first study to relate the clinical signs observed the mallards to
biochemical markers. Lead
inhibits antioxidant enzymes and interacts with sulfhydryl groups in proteins,
but had only minor effects on lipid peroxidation.
Strategy and Approach: Four groups of mallards were fed diets containing high or low levels of vitamin E (20 or 220 UI/kg), an antioxidant, and high or low levels of lead (0 or 2000 mg/kg). The birds were observed for neurologic impairment, changes in glutathione and related enzymes, and histopathological injury.
| ||Keywords||birds, contaminants, toxicology, waterfowl, wildlife, lead|
| ||Principal Investigator||Nelson Beyer, USGS Patuxent Wildlife Research Center: Nelson_Beyer@usgs.gov|